For many years, there was not an effective approach to treating relapsed pediatric or young adult cancers. Cincinnati Children’s oncologists specialize in the treatment of relapsed cancers and the center treats over 400 patients with these cancers each year. Our team has pioneered the use of next-generation tumor sequencing to identify novel cancer-driving genetic changes, and is using this information to guide personalized treatment with new anticancer drugs. At the 2017 Annual Meeting of the American Society for Clinical Oncology in Chicago, Erin Breese, MD, PhD, and Brian Turpin, DO, presented the Cincinnati Children’s experience with genomic-guided treatment – the largest, single-institution pediatric experience in the nation. The presentation demonstrated dramatic cancer remissions in patients who had relapsed despite multiple intensive chemotherapy regimens, bone marrow transplant and radiation. These findings are setting the new standard for care for children and young adults with relapsed cancers.